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Structural Basis of Allosteric Activation of Sterile α Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates

Sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) plays a critical role in inhibiting HIV infection, curtailing the pool of dNTPs available for reverse transcription of the viral genome. Recent structural data suggested a compelling mechanism for the regulation of SAMHD1 e...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Koharudin, Leonardus M. I., Wu, Ying, DeLucia, Maria, Mehrens, Jennifer, Gronenborn, Angela M., Ahn, Jinwoo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239615/
https://ncbi.nlm.nih.gov/pubmed/25288794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.591958
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