Allosteric Regulation of the Human and Mouse Deoxyribonucleotide Triphosphohydrolase Sterile α-Motif/Histidine-Aspartate Domain-containing Protein 1 (SAMHD1)

The deoxyribonucleotide triphosphohydrolase SAMHD1 restricts lentiviral infection by depleting the dNTPs required for viral DNA synthesis. In cultured human fibroblasts SAMHD1 is expressed maximally during quiescence preventing accumulation of dNTPs outside S phase. siRNA silencing of SAMHD1 increas...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Miazzi, Cristina, Ferraro, Paola, Pontarin, Giovanna, Rampazzo, Chiara, Reichard, Peter, Bianchi, Vera
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140260/
https://ncbi.nlm.nih.gov/pubmed/24828500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.571091
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados