The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592

SAMHD1 is the major catabolic enzyme regulating the intracellular concentrations of DNA precursors (dNTPs). The S-phase kinase CDK2-cyclinA phosphorylates SAMHD1 at Thr-592. How this modification affects SAMHD1 function is highly debated. We investigated the role of endogenous SAMHD1 phosphorylation...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Tramentozzi, Elisa, Ferraro, Paola, Hossain, Manzar, Stillman, Bruce, Bianchi, Vera, Pontarin, Giovanna
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110608/
https://ncbi.nlm.nih.gov/pubmed/30039733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1480216
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