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Substrate specificity of SAMHD1 triphosphohydrolase activity is controlled by deoxyribonucleoside triphosphates and phosphorylation at Thr592
Sterile alpha motif (SAM) and Histidine-Aspartate (HD)-domain containing protein 1 (SAMHD1) is a triphosphohydrolase that converts deoxyribonucleoside triphosphates (dNTPs) into deoxyribonucleosides and triphosphates. SAMHD1 exists in multiple states. The monomer and apo- or GTP-bound dimer are cata...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5225984/ https://ncbi.nlm.nih.gov/pubmed/27588835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00627 |
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