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Substrate specificity of SAMHD1 triphosphohydrolase activity is controlled by deoxyribonucleoside triphosphates and phosphorylation at Thr592

Sterile alpha motif (SAM) and Histidine-Aspartate (HD)-domain containing protein 1 (SAMHD1) is a triphosphohydrolase that converts deoxyribonucleoside triphosphates (dNTPs) into deoxyribonucleosides and triphosphates. SAMHD1 exists in multiple states. The monomer and apo- or GTP-bound dimer are cata...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Jang, Sunbok, Zhou, Xiaohong, Ahn, Jinwoo
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225984/
https://ncbi.nlm.nih.gov/pubmed/27588835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00627
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