Mechanisms of Allosteric Activation and Inhibition of the Deoxyribonucleoside Triphosphate Triphosphohydrolase from Enterococcus faecalis

EF1143 from Enterococcus faecalis, a life-threatening pathogen that is resistant to common antibiotics, is a homo-tetrameric deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase (dNTPase), converting dNTPs into the deoxyribonucleosides and triphosphate. The dNTPase activity of EF1143 is regul...

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Detalhes bibliográficos
Main Authors: Vorontsov, Ivan I., Wu, Ying, DeLucia, Maria, Minasov, George, Mehrens, Jennifer, Shuvalova, Ludmilla, Anderson, Wayne F., Ahn, Jinwoo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908413/
https://ncbi.nlm.nih.gov/pubmed/24338016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.524207
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