Deoxyribonucleotide Metabolism in Cycling and Resting Human Fibroblasts with a Missense Mutation in p53R2, a Subunit of Ribonucleotide Reductase

Ribonucleotide reduction provides deoxynucleotides for nuclear and mitochondrial (mt) DNA replication and DNA repair. In cycling mammalian cells the reaction is catalyzed by two proteins, R1 and R2. A third protein, p53R2, with the same function as R2, occurs in minute amounts. In quiescent cells, p...

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Detalhes bibliográficos
Main Authors: Pontarin, Giovanna, Ferraro, Paola, Rampazzo, Chiara, Kollberg, Gittan, Holme, Elisabeth, Reichard, Peter, Bianchi, Vera
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064167/
https://ncbi.nlm.nih.gov/pubmed/21297166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.202283
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