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Deoxyribonucleotide Metabolism in Cycling and Resting Human Fibroblasts with a Missense Mutation in p53R2, a Subunit of Ribonucleotide Reductase

Ribonucleotide reduction provides deoxynucleotides for nuclear and mitochondrial (mt) DNA replication and DNA repair. In cycling mammalian cells the reaction is catalyzed by two proteins, R1 and R2. A third protein, p53R2, with the same function as R2, occurs in minute amounts. In quiescent cells, p...

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Main Authors: Pontarin, Giovanna, Ferraro, Paola, Rampazzo, Chiara, Kollberg, Gittan, Holme, Elisabeth, Reichard, Peter, Bianchi, Vera
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064167/
https://ncbi.nlm.nih.gov/pubmed/21297166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.202283
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