Loading...

Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells

In postmitotic mammalian cells, protein p53R2 substitutes for protein R2 as a subunit of ribonucleotide reductase. In human patients with mutations in RRM2B, the gene for p53R2, mitochondrial (mt) DNA synthesis is defective, and skeletal muscle presents severe mtDNA depletion. Skin fibroblasts isola...

Full description

Saved in:
Bibliographic Details
Main Authors: Pontarin, Giovanna, Ferraro, Paola, Bee, Leonardo, Reichard, Peter, Bianchi, Vera
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421225/
https://ncbi.nlm.nih.gov/pubmed/22847445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211289109
Tags: Add Tag
No Tags, Be the first to tag this record!