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Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells

In postmitotic mammalian cells, protein p53R2 substitutes for protein R2 as a subunit of ribonucleotide reductase. In human patients with mutations in RRM2B, the gene for p53R2, mitochondrial (mt) DNA synthesis is defective, and skeletal muscle presents severe mtDNA depletion. Skin fibroblasts isola...

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Bibliographische Detailangaben
Hauptverfasser: Pontarin, Giovanna, Ferraro, Paola, Bee, Leonardo, Reichard, Peter, Bianchi, Vera
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421225/
https://ncbi.nlm.nih.gov/pubmed/22847445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211289109
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