Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs). However, oxygen is an essential cofactor for mam...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Foskolou, Iosifina P., Jorgensen, Christian, Leszczynska, Katarzyna B., Olcina, Monica M., Tarhonskaya, Hanna, Haisma, Bauke, D’Angiolella, Vincenzo, Myers, William K., Domene, Carmen, Flashman, Emily, Hammond, Ester M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405111/
https://ncbi.nlm.nih.gov/pubmed/28416140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.005
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