Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT

Restoration of hypoxia-induced apoptosis in tumors harboring p53 mutations has been proposed as a potential therapeutic strategy; however, the transcriptional targets that mediate hypoxia-induced p53-dependent apoptosis remain elusive. Here, we demonstrated that hypoxia-induced p53-dependent apoptos...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Leszczynska, Katarzyna B., Foskolou, Iosifina P., Abraham, Aswin G., Anbalagan, Selvakumar, Tellier, Céline, Haider, Syed, Span, Paul N., O’Neill, Eric E., Buffa, Francesca M., Hammond, Ester M.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497762/
https://ncbi.nlm.nih.gov/pubmed/25961455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80402
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