Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

ATM-mediated signaling in response to DNA damage is a barrier to tumorigenesis. Here we asked whether replication stress could also contribute to ATM signaling. We demonstrate that, in the absence of DNA damage, ATM responds to replication stress in a hypoxia-induced heterochromatin-like context. In...

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Autores principales: Olcina, Monica M., Foskolou, Iosifina P., Anbalagan, Selvakumar, Senra, Joana M., Pires, Isabel M., Jiang, Yanyan, Ryan, Anderson J., Hammond, Ester M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2013
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Short Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898930/
https://ncbi.nlm.nih.gov/pubmed/24268576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.019
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