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ATM Activation and Signaling under Hypoxic Conditions
The ATM kinase has previously been shown to respond to the DNA damage induced by reoxygenation following hypoxia by initiating a Chk 2-dependent cell cycle arrest in the G(2) phase. Here we show that ATM is both phosphorylated and active during exposure to hypoxia in the absence of DNA damage, detec...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2612523/ https://ncbi.nlm.nih.gov/pubmed/18981219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01301-08 |
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