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mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α
The mTOR complex-1 (mTORC1) coordinates cell growth and metabolism, acting as a restriction point under stress conditions such as low oxygen tension (hypoxia). Hypoxia suppresses mTORC1 signaling. However, the signals by which hypoxia suppresses mTORC1 are only partially understood, and a direct lin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3004768/ https://ncbi.nlm.nih.gov/pubmed/21095582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.10.030 |
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