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Targeting hypoxic cells through the DNA damage response
Exposure to hypoxia-induced replication arrest initiates a DNA damage response which includes both ATR and ATM-mediated signalling. DNA fiber analysis was used to show that these conditions lead to a replication arrest during both the initiation and elongation phases and that this correlated with de...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3000384/ https://ncbi.nlm.nih.gov/pubmed/20876254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0286 |
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