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Targeting hypoxic cells through the DNA damage response

Exposure to hypoxia-induced replication arrest initiates a DNA damage response which includes both ATR and ATM-mediated signalling. DNA fiber analysis was used to show that these conditions lead to a replication arrest during both the initiation and elongation phases and that this correlated with de...

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Bibliografske podrobnosti
Main Authors: Olcina, Monica, Lecane, Philip S., Hammond, Ester M.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000384/
https://ncbi.nlm.nih.gov/pubmed/20876254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0286
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