Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

ATM-mediated signaling in response to DNA damage is a barrier to tumorigenesis. Here we asked whether replication stress could also contribute to ATM signaling. We demonstrate that, in the absence of DNA damage, ATM responds to replication stress in a hypoxia-induced heterochromatin-like context. In...

Full description

Saved in:
Bibliographic Details
Main Authors: Olcina, Monica M., Foskolou, Iosifina P., Anbalagan, Selvakumar, Senra, Joana M., Pires, Isabel M., Jiang, Yanyan, Ryan, Anderson J., Hammond, Ester M.
Format: Artigo
Language:Inglês
Published: Cell Press 2013
Subjects:
Short Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898930/
https://ncbi.nlm.nih.gov/pubmed/24268576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.019
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items