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Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication
ATM-mediated signaling in response to DNA damage is a barrier to tumorigenesis. Here we asked whether replication stress could also contribute to ATM signaling. We demonstrate that, in the absence of DNA damage, ATM responds to replication stress in a hypoxia-induced heterochromatin-like context. In...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Cell Press
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3898930/ https://ncbi.nlm.nih.gov/pubmed/24268576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.019 |
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