Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs). However, oxygen is an essential cofactor for mam...

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Bibliografiset tiedot
Julkaisussa:Mol Cell
Päätekijät: Foskolou, Iosifina P., Jorgensen, Christian, Leszczynska, Katarzyna B., Olcina, Monica M., Tarhonskaya, Hanna, Haisma, Bauke, D’Angiolella, Vincenzo, Myers, William K., Domene, Carmen, Flashman, Emily, Hammond, Ester M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405111/
https://ncbi.nlm.nih.gov/pubmed/28416140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.005
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