Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage

Ribonucleotide reductase provides deoxynucleotides for nuclear and mitochondrial (mt) DNA replication and repair. The mammalian enzyme consists of a catalytic (R1) and a radical-generating (R2 or p53R2) subunit. During S-phase, a R1/R2 complex is the major provider of deoxynucleotides. p53R2 is indu...

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Detalhes bibliográficos
Main Authors: Pontarin, Giovanna, Fijolek, Artur, Pizzo, Paola, Ferraro, Paola, Rampazzo, Chiara, Pozzan, Tullio, Thelander, Lars, Reichard, Peter A., Bianchi, Vera
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584719/
https://ncbi.nlm.nih.gov/pubmed/18997010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808198105
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