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Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage
Ribonucleotide reductase provides deoxynucleotides for nuclear and mitochondrial (mt) DNA replication and repair. The mammalian enzyme consists of a catalytic (R1) and a radical-generating (R2 or p53R2) subunit. During S-phase, a R1/R2 complex is the major provider of deoxynucleotides. p53R2 is indu...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2584719/ https://ncbi.nlm.nih.gov/pubmed/18997010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808198105 |
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