Allosteric Regulation of the Human and Mouse Deoxyribonucleotide Triphosphohydrolase Sterile α-Motif/Histidine-Aspartate Domain-containing Protein 1 (SAMHD1)

The deoxyribonucleotide triphosphohydrolase SAMHD1 restricts lentiviral infection by depleting the dNTPs required for viral DNA synthesis. In cultured human fibroblasts SAMHD1 is expressed maximally during quiescence preventing accumulation of dNTPs outside S phase. siRNA silencing of SAMHD1 increas...

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Autores principales: Miazzi, Cristina, Ferraro, Paola, Pontarin, Giovanna, Rampazzo, Chiara, Reichard, Peter, Bianchi, Vera
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140260/
https://ncbi.nlm.nih.gov/pubmed/24828500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.571091
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