Structural Basis of Clade-specific Engagement of SAMHD1 (Sterile α Motif and Histidine/Aspartate-containing Protein 1) Restriction Factors by Lentiviral Viral Protein X (Vpx) Virulence Factors

Sterile α motif (SAM) and histidine/aspartate (HD)-containing protein 1 (SAMHD1) restricts human/simian immunodeficiency virus infection in certain cell types and is counteracted by the virulence factor Vpx. Current evidence indicates that Vpx recruits SAMHD1 to the Cullin4-Ring Finger E3 ubiquitin...

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Vydáno v:J Biol Chem
Hlavní autoři: Wu, Ying, Koharudin, Leonardus M. I., Mehrens, Jennifer, DeLucia, Maria, Byeon, Chang-Hyeok, Byeon, In-Ja L., Calero, Guillermo, Ahn, Jinwoo, Gronenborn, Angela M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505041/
https://ncbi.nlm.nih.gov/pubmed/26045556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.665513
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