MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides like O6-methyl-dGTP can be mutagenic and toxic if incorporated into DNA. Removal of methylated nucleotides from the nucleotide pool may therefore be impo...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Jemth, Ann-Sofie, Gustafsson, Robert, Bräutigam, Lars, Henriksson, Linda, Vallin, Karl S A, Sarno, Antonio, Almlöf, Ingrid, Homan, Evert, Rasti, Azita, Warpman Berglund, Ulrika, Stenmark, Pål, Helleday, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237811/
https://ncbi.nlm.nih.gov/pubmed/30304478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky896
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