Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids

nork Pettke, Aleksandra, Tampere, Marianna, Pronk, Robin, Wallner, Olov, Falk, Anna, Warpman Berglund, Ulrika, Helleday, Thomas, Mirazimi, Ali, Puumalainen, Marjo-Riitta
Argitaratua izan da Viruses (2020)

Computational and Experimental Druggability Assessment of Human DNA Glycosylases

nork Michel, Maurice, Visnes, Torkild, Homan, Evert J., Seashore-Ludlow, Brinton, Hedenström, Mattias, Wiita, Elisée, Vallin, Karl, Paulin, Cynthia B. J., Zhang, Jiaxi, Wallner, Olov, Scobie, Martin, Schmidt, Andreas, Jenmalm-Jensen, Annika, Warpman Berglund, Ulrika, Helleday, Thomas
Argitaratua izan da ACS Omega (2019)

Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

nork Baquero, Juan Miguel, Benítez-Buelga, Carlos, Rajagopal, Varshni, Zhenjun, Zhao, Torres-Ruiz, Raúl, Müller, Sarah, Hanna, Bishoy M. F., Loseva, Olga, Wallner, Olov, Michel, Maurice, Rodríguez-Perales, Sandra, Gad, Helge, Visnes, Torkild, Helleday, Thomas, Benítez, Javier, Osorio, Ana
Argitaratua izan da Sci Rep (2021)

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

nork Rehling, Daniel, Zhang, Si Min, Jemth, Ann-Sofie, Koolmeister, Tobias, Throup, Adam, Wallner, Olov, Scaletti, Emma, Moriyama, Takaya, Nishii, Rina, Davies, Jonathan, Desroses, Matthieu, Rudd, Sean G., Scobie, Martin, Homan, Evert, Berglund, Ulrika Warpman, Yang, Jun J., Helleday, Thomas, Stenmark, Pål
Argitaratua izan da J Biol Chem (2021)

Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses

nork Tampere, Marianna, Pettke, Aleksandra, Salata, Cristiano, Wallner, Olov, Koolmeister, Tobias, Cazares-Körner, Armando, Visnes, Torkild, Hesselman, Maria Carmen, Kunold, Elena, Wiita, Elisee, Kalderén, Christina, Lightowler, Molly, Jemth, Ann-Sofie, Lehtiö, Janne, Rosenquist, Åsa, Warpman-Berglund, Ulrika, Helleday, Thomas, Mirazimi, Ali, Jafari, Rozbeh, Puumalainen, Marjo-Riitta
Argitaratua izan da Viruses (2020)

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

nork Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Argitaratua izan da Nat Commun (2018)

Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

nork Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Argitaratua izan da Nat Commun (2019)

Development of a chemical probe against NUDT15

nork Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C.K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas
Argitaratua izan da Nat Chem Biol (2020)

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

nork Visnes, Torkild, Cázares-Körner, Armando, Hao, Wenjing, Wallner, Olov, Masuyer, Geoffrey, Loseva, Olga, Mortusewicz, Oliver, Wiita, Elisée, Sarno, Antonio, Manoilov, Aleksandr, Astorga-Wells, Juan, Jemth, Ann-Sofie, Pan, Lang, Sanjiv, Kumar, Karsten, Stella, Gokturk, Camilla, Grube, Maurice, Homan, Evert J., Hanna, Bishoy M. F., Paulin, Cynthia B. J., Pham, Therese, Rasti, Azita, Berglund, Ulrika Warpman, von Nicolai, Catharina, Benitez-Buelga, Carlos, Koolmeister, Tobias, Ivanic, Dag, Iliev, Petar, Scobie, Martin, Krokan, Hans E., Baranczewski, Pawel, Artursson, Per, Altun, Mikael, Jensen, Annika Jenmalm, Kalderén, Christina, Ba, Xueqing, Zubarev, Roman A., Stenmark, Pål, Boldogh, Istvan, Helleday, Thomas
Argitaratua izan da Science (2018)

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

nork Visnes, Torkild, Benítez-Buelga, Carlos, Cázares-Körner, Armando, Sanjiv, Kumar, Hanna, Bishoy M F, Mortusewicz, Oliver, Rajagopal, Varshni, Albers, Julian J, Hagey, Daniel W, Bekkhus, Tove, Eshtad, Saeed, Baquero, Juan Miguel, Masuyer, Geoffrey, Wallner, Olov, Müller, Sarah, Pham, Therese, Göktürk, Camilla, Rasti, Azita, Suman, Sharda, Torres-Ruiz, Raúl, Sarno, Antonio, Wiita, Elisée, Homan, Evert J, Karsten, Stella, Marimuthu, Karthick, Michel, Maurice, Koolmeister, Tobias, Scobie, Martin, Loseva, Olga, Almlöf, Ingrid, Unterlass, Judith Edda, Pettke, Aleksandra, Boström, Johan, Pandey, Monica, Gad, Helge, Herr, Patrick, Jemth, Ann-Sofie, El Andaloussi, Samir, Kalderén, Christina, Rodriguez-Perales, Sandra, Benítez, Javier, Krokan, Hans E, Altun, Mikael, Stenmark, Pål, Berglund, Ulrika Warpman, Helleday, Thomas
Argitaratua izan da Nucleic Acids Res (2020)