Glioblastoma and glioblastoma stem cells are dependent on functional MTH1

av Pudelko, Linda, Rouhi, Pegah, Sanjiv, Kumar, Gad, Helge, Kalderén, Christina, Höglund, Andreas, Squatrito, Massimo, Schuhmacher, Alberto J., Edwards, Steven, Hägerstrand, Daniel, Berglund, Ulrika Warpman, Helleday, Thomas, Bräutigam, Lars
I publikationen Oncotarget (2017)

Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1

av Pudelko, Linda, Rouhi, Pegah, Sanjiv, Kumar, Gad, Helge, Kalderén, Christina, Höglund, Andreas, Squatrito, Massimo, Schuhmacher, Alberto J., Edwards, Steven, Hägerstrand, Daniel, Berglund, Ulrika Warpman, Helleday, Thomas, Bräutigam, Lars
I publikationen Oncotarget (2020)

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model

av Moukengue, Brice, Brown, Hannah K, Charrier, Céline, Battaglia, Séverine, Baud'huin, Marc, Quillard, Thibaut, Pham, Therese M, Pateras, Ioannis S, Gorgoulis, Vassilis G, Helleday, Thomas, Heymann, Dominique, Berglund, Ulrika Warpman, Ory, Benjamin, Lamoureux, Francois
I publikationen EBioMedicine (2020)

Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma

av Oksvold, Morten P., Berglund, Ulrika Warpman, Gad, Helge, Bai, Baoyan, Stokke, Trond, Rein, Idun Dale, Pham, Therese, Sanjiv, Kumar, Øy, Geir Frode, Norum, Jens Henrik, Smeland, Erlend B., Myklebust, June H., Helleday, Thomas, Våtsveen, Thea Kristin
I publikationen Sci Rep (2021)

Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics

av Lallo, Alice, Gulati, Sakshi, Schenk, Maximilian W, Khandelwal, Garima, Berglund, Ulrika Warpman, Pateras, Ioannis S, Chester, Christopher P E, Pham, Therese M, Kalderen, Christina, Frese, Kristopher K, Gorgoulis, Vassilis G, Miller, Crispin, Blackhall, Fiona, Helleday, Thomas, Dive, Caroline
I publikationen Br J Pharmacol (2018)

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

av Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Charlton, Peter A., Pollard, John R., Berglund, Ulrika Warpman, Altun, Mikael, Helleday, Thomas
I publikationen Cell Rep (2015)

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

av Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Charlton, Peter A., Pollard, John R., Berglund, Ulrika Warpman, Altun, Mikael, Helleday, Thomas
I publikationen Cell Rep (2016)

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

av Rehling, Daniel, Zhang, Si Min, Jemth, Ann-Sofie, Koolmeister, Tobias, Throup, Adam, Wallner, Olov, Scaletti, Emma, Moriyama, Takaya, Nishii, Rina, Davies, Jonathan, Desroses, Matthieu, Rudd, Sean G., Scobie, Martin, Homan, Evert, Berglund, Ulrika Warpman, Yang, Jun J., Helleday, Thomas, Stenmark, Pål
I publikationen J Biol Chem (2021)

Stereospecific targeting of MTH1 by (S)-crizotinib as anticancer strategy

av Huber, Kilian V. M., Salah, Eidarus, Radic, Branka, Gridling, Manuela, Elkins, Jonathan M., Stukalov, Alexey, Jemth, Ann-Sofie, Gokturk, Camilla, Sanjiv, Kumar, Strömberg, Kia, Pham, Therese, Berglund, Ulrika Warpman, Colinge, Jacques, Bennett, Keiryn L., Loizou, Joanna, Helleday, Thomas, Knapp, Stefan, Superti-Furga, Giulio
Publicerad 2014

Global survey of the immunomodulatory potential of common drugs

av Vladimer, Gregory I., Snijder, Berend, Krall, Nikolaus, Bigenzahn, Johannes W., Huber, Kilian V.M., Lardeau, Charles-Hugues, Sanjiv, Kumar, Ringler, Anna, Berglund, Ulrika Warpman, Sabler, Monika, de la Fuente, Oscar Lopez, Knöbl, Paul, Kubicek, Stefan, Helleday, Thomas, Jäger, Ulrich, Superti-Furga, Giulio
I publikationen Nat Chem Biol (2017)

A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma

av Einarsdottir, Berglind O., Karlsson, Joakim, Söderberg, Elin M. V., Lindberg, Mattias F., Funck-Brentano, Elisa, Jespersen, Henrik, Brynjolfsson, Siggeir F., Olofsson Bagge, Roger, Carstam, Louise, Scobie, Martin, Koolmeister, Tobias, Wallner, Olof, Stierner, Ulrika, Berglund, Ulrika Warpman, Ny, Lars, Nilsson, Lisa M., Larsson, Erik, Helleday, Thomas, Nilsson, Jonas A.
I publikationen Cell Death Dis (2018)

Correction: A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma

av Einarsdottir, Berglind O., Karlsson, Joakim, Söderberg, Elin M. V., Lindberg, Mattias F., Funck-Brentano, Elisa, Jespersen, Henrik, Brynjolfsson, Siggeir F., Bagge, Roger Olofsson, Carstam, Louise, Scobie, Martin, Koolmeister, Tobias, Wallner, Olof, Stierner, Ulrika, Berglund, Ulrika Warpman, Ny, Lars, Nilsson, Lisa M., Larsson, Erik, Helleday, Thomas, Nilsson, Jonas A.
I publikationen Cell Death Dis (2020)

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

av Llona-Minguez, Sabin, Höglund, Andreas, Jacques, Sylvain A., Johansson, Lars, Calderón-Montaño, José Manuel, Claesson, Magnus, Loseva, Olga, Valerie, Nicholas C. K., Lundbäck, Thomas, Piedrafita, Javier, Maga, Giovanni, Crespan, Emmanuele, Meijer, Laurent, Morón, Estefanía Burgos, Baranczewski, Pawel, Hagbjörk, Ann-Louise, Svensson, Richard, Wiita, Elisee, Almlöf, Ingrid, Visnes, Torkild, Jeppsson, Fredrik, Sigmundsson, Kristmundur, Jensen, Annika Jenmalm, Artursson, Per, Jemth, Ann-Sofie, Stenmark, Pål, Berglund, Ulrika Warpman, Scobie, Martin, Helleday, Thomas
I publikationen J Med Chem (2016)

Development of a chemical probe against NUDT15

av Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C.K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas
I publikationen Nat Chem Biol (2020)

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

av Visnes, Torkild, Cázares-Körner, Armando, Hao, Wenjing, Wallner, Olov, Masuyer, Geoffrey, Loseva, Olga, Mortusewicz, Oliver, Wiita, Elisée, Sarno, Antonio, Manoilov, Aleksandr, Astorga-Wells, Juan, Jemth, Ann-Sofie, Pan, Lang, Sanjiv, Kumar, Karsten, Stella, Gokturk, Camilla, Grube, Maurice, Homan, Evert J., Hanna, Bishoy M. F., Paulin, Cynthia B. J., Pham, Therese, Rasti, Azita, Berglund, Ulrika Warpman, von Nicolai, Catharina, Benitez-Buelga, Carlos, Koolmeister, Tobias, Ivanic, Dag, Iliev, Petar, Scobie, Martin, Krokan, Hans E., Baranczewski, Pawel, Artursson, Per, Altun, Mikael, Jensen, Annika Jenmalm, Kalderén, Christina, Ba, Xueqing, Zubarev, Roman A., Stenmark, Pål, Boldogh, Istvan, Helleday, Thomas
I publikationen Science (2018)

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

av Visnes, Torkild, Benítez-Buelga, Carlos, Cázares-Körner, Armando, Sanjiv, Kumar, Hanna, Bishoy M F, Mortusewicz, Oliver, Rajagopal, Varshni, Albers, Julian J, Hagey, Daniel W, Bekkhus, Tove, Eshtad, Saeed, Baquero, Juan Miguel, Masuyer, Geoffrey, Wallner, Olov, Müller, Sarah, Pham, Therese, Göktürk, Camilla, Rasti, Azita, Suman, Sharda, Torres-Ruiz, Raúl, Sarno, Antonio, Wiita, Elisée, Homan, Evert J, Karsten, Stella, Marimuthu, Karthick, Michel, Maurice, Koolmeister, Tobias, Scobie, Martin, Loseva, Olga, Almlöf, Ingrid, Unterlass, Judith Edda, Pettke, Aleksandra, Boström, Johan, Pandey, Monica, Gad, Helge, Herr, Patrick, Jemth, Ann-Sofie, El Andaloussi, Samir, Kalderén, Christina, Rodriguez-Perales, Sandra, Benítez, Javier, Krokan, Hans E, Altun, Mikael, Stenmark, Pål, Berglund, Ulrika Warpman, Helleday, Thomas
I publikationen Nucleic Acids Res (2020)