Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

[Image: see text] The dCTPase pyrophosphatase 1 (dCTPase) regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs). dCTPase is highly expressed in multiple carcinomas and is associated with cancer cell stemness. Here we...

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Publicado no:J Med Chem
Main Authors: Llona-Minguez, Sabin, Höglund, Andreas, Jacques, Sylvain A., Johansson, Lars, Calderón-Montaño, José Manuel, Claesson, Magnus, Loseva, Olga, Valerie, Nicholas C. K., Lundbäck, Thomas, Piedrafita, Javier, Maga, Giovanni, Crespan, Emmanuele, Meijer, Laurent, Morón, Estefanía Burgos, Baranczewski, Pawel, Hagbjörk, Ann-Louise, Svensson, Richard, Wiita, Elisee, Almlöf, Ingrid, Visnes, Torkild, Jeppsson, Fredrik, Sigmundsson, Kristmundur, Jensen, Annika Jenmalm, Artursson, Per, Jemth, Ann-Sofie, Stenmark, Pål, Berglund, Ulrika Warpman, Scobie, Martin, Helleday, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753678/
https://ncbi.nlm.nih.gov/pubmed/26771665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01741
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