TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model

BACKGROUND: Osteosarcoma (OS) is the most common primary malignant bone tumour. Unfortunately, no new treatments are approved and over the last 30 years the survival rate remains only 30% at 5 years for poor responders justifying an urgent need of new therapies. The Mutt homolog 1 (MTH1) enzyme prev...

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Detalles Bibliográficos
Publicado en:EBioMedicine
Main Authors: Moukengue, Brice, Brown, Hannah K, Charrier, Céline, Battaglia, Séverine, Baud'huin, Marc, Quillard, Thibaut, Pham, Therese M, Pateras, Ioannis S, Gorgoulis, Vassilis G, Helleday, Thomas, Heymann, Dominique, Berglund, Ulrika Warpman, Ory, Benjamin, Lamoureux, Francois
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
Assuntos:
Research paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063190/
https://ncbi.nlm.nih.gov/pubmed/32151797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102704
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