Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is increased after CHK1 inhibition, we hypothesized that this may indicate an increased reliance on ATR for survival. Indeed, we observe that r...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Charlton, Peter A., Pollard, John R., Berglund, Ulrika Warpman, Altun, Mikael, Helleday, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713868/
https://ncbi.nlm.nih.gov/pubmed/26748709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.032
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados