Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer

Topoisomerase IIβ-binding protein 1 (TopBP1) is involved in cellular replication among other functions and is known to activate ATR/Chk1 during replicative stress. TopBP1 is also expressed at high levels in many cancers. However, the impact of TopBP1 overexpression on ATR/Chk1 activation and cancer...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Liu, Kang, Graves, Joshua D., Lin, Fang-Tsyr, Lin, Weei-Chin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949146/
https://ncbi.nlm.nih.gov/pubmed/33556369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100382
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