Laddar...
Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer
Topoisomerase IIβ-binding protein 1 (TopBP1) is involved in cellular replication among other functions and is known to activate ATR/Chk1 during replicative stress. TopBP1 is also expressed at high levels in many cancers. However, the impact of TopBP1 overexpression on ATR/Chk1 activation and cancer...
Sparad:
| I publikationen: | J Biol Chem |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Biochemistry and Molecular Biology
2021
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7949146/ https://ncbi.nlm.nih.gov/pubmed/33556369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100382 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|