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Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation
TopBP1 and Claspin are adaptor proteins that facilitate phosphorylation of Chk1 by the ATR kinase in response to genotoxic stress. Despite their established requirement for Chk1 activation, the exact way in which TopBP1 and Claspin control Chk1 phosphorylation remains unclear. We show that TopBP1 ti...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1592810/ https://ncbi.nlm.nih.gov/pubmed/16880517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00492-06 |
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