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Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation

TopBP1 and Claspin are adaptor proteins that facilitate phosphorylation of Chk1 by the ATR kinase in response to genotoxic stress. Despite their established requirement for Chk1 activation, the exact way in which TopBP1 and Claspin control Chk1 phosphorylation remains unclear. We show that TopBP1 ti...

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Detalhes bibliográficos
Main Authors: Liu, Shizhou, Bekker-Jensen, Simon, Mailand, Niels, Lukas, Claudia, Bartek, Jiri, Lukas, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592810/
https://ncbi.nlm.nih.gov/pubmed/16880517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00492-06
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