Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation

TopBP1 and Claspin are adaptor proteins that facilitate phosphorylation of Chk1 by the ATR kinase in response to genotoxic stress. Despite their established requirement for Chk1 activation, the exact way in which TopBP1 and Claspin control Chk1 phosphorylation remains unclear. We show that TopBP1 ti...

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Bibliographic Details
Main Authors: Liu, Shizhou, Bekker-Jensen, Simon, Mailand, Niels, Lukas, Claudia, Bartek, Jiri, Lukas, Jiri
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592810/
https://ncbi.nlm.nih.gov/pubmed/16880517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00492-06
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