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USP7 counteracts SCF(βTrCP)- but not APC(Cdh1)-mediated proteolysis of Claspin
Claspin is an adaptor protein that facilitates the ataxia telangiectasia and Rad3-related (ATR)-mediated phosphorylation and activation of Chk1, a key effector kinase in the DNA damage response. Efficient termination of Chk1 signaling in mitosis and during checkpoint recovery requires SCF(βTrCP)-dep...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2615094/ https://ncbi.nlm.nih.gov/pubmed/19124652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200807137 |
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