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Dual Effects of IκB Kinase β-Mediated Phosphorylation on p105 Fate: SCF(β-TrCP)-Dependent Degradation and SCF(β-TrCP)-Independent Processing

Processing of the p105 NF-κB precursor to yield the p50 active subunit is a unique and rare case in which the ubiquitin system is involved in limited processing rather than in complete destruction of its target. The mechanisms involved in this process are largely unknown, although a glycine repeat i...

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Autori principali: Cohen, Shai, Achbert-Weiner, Hillit, Ciechanover, Aaron
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC303339/
https://ncbi.nlm.nih.gov/pubmed/14673179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.1.475-486.2004
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