Pseudosubstrate regulation of the SCF(β-TrCP) ubiquitin ligase by hnRNP-U

β-TrCP/E3RS (E3RS) is the F-box protein that functions as the receptor subunit of the SCF(β-TrCP) ubiquitin ligase (E3). Surprisingly, although its two recognized substrates, IκBα and β-catenin, are present in the cytoplasm, we have found that E3RS is located predominantly in the nucleus. Here we re...

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Detalhes bibliográficos
Main Authors: Davis, Matti, Hatzubai, Ada, Andersen, Jens S., Ben-Shushan, Etti, Fisher, Gregory Zvi, Yaron, Avraham, Bauskin, Asne, Mercurio, Frank, Mann, Matthias, Ben-Neriah, Yinon
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155337/
https://ncbi.nlm.nih.gov/pubmed/11850407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.218702
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