βTrCP-Mediated Proteolysis of NF-κB1 p105 Requires Phosphorylation of p105 Serines 927 and 932

NF-κB1 p105 functions both as a precursor of NF-κB1 p50 and as a cytoplasmic inhibitor of NF-κB. Following the stimulation of cells with tumor necrosis factor alpha (TNF-α), the IκB kinase (IKK) complex rapidly phosphorylates NF-κB1 p105 on serine 927 in the PEST region. This phosphorylation is esse...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Lang, Valerie, Janzen, Julia, Fischer, Gregory Zvi, Soneji, Yasmina, Beinke, Sören, Salmeron, Andres, Allen, Hamish, Hay, Ronald T., Ben-Neriah, Yinon, Ley, Steven C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140687/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12482991/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.1.402-413.2003
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