βTrCP-Mediated Proteolysis of NF-κB1 p105 Requires Phosphorylation of p105 Serines 927 and 932

NF-κB1 p105 functions both as a precursor of NF-κB1 p50 and as a cytoplasmic inhibitor of NF-κB. Following the stimulation of cells with tumor necrosis factor alpha (TNF-α), the IκB kinase (IKK) complex rapidly phosphorylates NF-κB1 p105 on serine 927 in the PEST region. This phosphorylation is esse...

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Autores principales: Lang, Valerie, Janzen, Julia, Fischer, Gregory Zvi, Soneji, Yasmina, Beinke, Sören, Salmeron, Andres, Allen, Hamish, Hay, Ronald T., Ben-Neriah, Yinon, Ley, Steven C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC140687/
https://ncbi.nlm.nih.gov/pubmed/12482991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.1.402-413.2003
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