USP17- and SCF(βTrCP)-Regulated Degradation of DEC1 Controls the DNA Damage Response

In response to genotoxic stress, DNA damage checkpoints maintain the integrity of the genome by delaying cell cycle progression to allow for DNA repair. Here we show that the degradation of the basic helix-loop-helix (bHLH) transcription factor DEC1, a critical regulator of cell fate and circadian r...

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Publicat a:Mol Cell Biol
Autors principals: Kim, Jihoon, D'Annibale, Sara, Magliozzi, Roberto, Low, Teck Yew, Jansen, Petra, Shaltiel, Indra A., Mohammed, Shabaz, Heck, Albert J. R., Medema, Rene H., Guardavaccaro, Daniele
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248718/
https://ncbi.nlm.nih.gov/pubmed/25202122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00530-14
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