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USP17- and SCF(βTrCP)-Regulated Degradation of DEC1 Controls the DNA Damage Response
In response to genotoxic stress, DNA damage checkpoints maintain the integrity of the genome by delaying cell cycle progression to allow for DNA repair. Here we show that the degradation of the basic helix-loop-helix (bHLH) transcription factor DEC1, a critical regulator of cell fate and circadian r...
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Publicado no: | Mol Cell Biol |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Microbiology
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4248718/ https://ncbi.nlm.nih.gov/pubmed/25202122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00530-14 |
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