USP17- and SCF(βTrCP)-Regulated Degradation of DEC1 Controls the DNA Damage Response

In response to genotoxic stress, DNA damage checkpoints maintain the integrity of the genome by delaying cell cycle progression to allow for DNA repair. Here we show that the degradation of the basic helix-loop-helix (bHLH) transcription factor DEC1, a critical regulator of cell fate and circadian r...

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Bibliografiska uppgifter
I publikationen:Mol Cell Biol
Huvudupphovsmän: Kim, Jihoon, D'Annibale, Sara, Magliozzi, Roberto, Low, Teck Yew, Jansen, Petra, Shaltiel, Indra A., Mohammed, Shabaz, Heck, Albert J. R., Medema, Rene H., Guardavaccaro, Daniele
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2014
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248718/
https://ncbi.nlm.nih.gov/pubmed/25202122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00530-14
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