USP17- and SCF(βTrCP)-Regulated Degradation of DEC1 Controls the DNA Damage Response

In response to genotoxic stress, DNA damage checkpoints maintain the integrity of the genome by delaying cell cycle progression to allow for DNA repair. Here we show that the degradation of the basic helix-loop-helix (bHLH) transcription factor DEC1, a critical regulator of cell fate and circadian r...

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Pubblicato in:Mol Cell Biol
Autori principali: Kim, Jihoon, D'Annibale, Sara, Magliozzi, Roberto, Low, Teck Yew, Jansen, Petra, Shaltiel, Indra A., Mohammed, Shabaz, Heck, Albert J. R., Medema, Rene H., Guardavaccaro, Daniele
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248718/
https://ncbi.nlm.nih.gov/pubmed/25202122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00530-14
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