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Degradation of Tiam1 by Casein Kinase 1 and the SCF(βTrCP) Ubiquitin Ligase Controls the Duration of mTOR-S6K Signaling
Tiam1 (T-cell lymphoma invasion and metastasis 1) is a guanine nucleotide exchange factor that specifically controls the activity of the small GTPase Rac, a key regulator of cell adhesion, proliferation, and survival. Here, we report that in response to mitogens, Tiam1 is degraded by the ubiquitin-p...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183780/ https://ncbi.nlm.nih.gov/pubmed/25124033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575571 |
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