TopBP1 and ATR Colocalization at Meiotic Chromosomes: Role of TopBP1/Cut5 in the Meiotic Recombination Checkpoint

Mammalian TopBP1 is a BRCT domain–containing protein whose function in mitotic cells is linked to replication and DNA damage checkpoint. Here, we study its possible role during meiosis in mice. TopBP1 foci are abundant during early prophase I and localize mainly to histone γ-H2AX–positive domains, w...

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Pubblicato in:Mol Biol Cell
Autori principali: Perera, David, Perez-Hidalgo, Livia, Moens, Peter B., Reini, Kaarina, Lakin, Nicholas, Syväoja, Juhani E., San-Segundo, Pedro A., Freire, Raimundo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Cell Biology 2004
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Articles
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC379256/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14718568/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E03-06-0444
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