TopBP1 and ATR Colocalization at Meiotic Chromosomes: Role of TopBP1/Cut5 in the Meiotic Recombination Checkpoint

Mammalian TopBP1 is a BRCT domain–containing protein whose function in mitotic cells is linked to replication and DNA damage checkpoint. Here, we study its possible role during meiosis in mice. TopBP1 foci are abundant during early prophase I and localize mainly to histone γ-H2AX–positive domains, w...

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Dades bibliogràfiques

Publicat a:	Mol Biol Cell
Autors principals:	Perera, David, Perez-Hidalgo, Livia, Moens, Peter B., Reini, Kaarina, Lakin, Nicholas, Syväoja, Juhani E., San-Segundo, Pedro A., Freire, Raimundo
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Cell Biology 2004
Matèries:	Articles
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC379256/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14718568/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E03-06-0444
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