TopBP1 and ATR Colocalization at Meiotic Chromosomes: Role of TopBP1/Cut5 in the Meiotic Recombination Checkpoint

Mammalian TopBP1 is a BRCT domain–containing protein whose function in mitotic cells is linked to replication and DNA damage checkpoint. Here, we study its possible role during meiosis in mice. TopBP1 foci are abundant during early prophase I and localize mainly to histone γ-H2AX–positive domains, w...

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Publicado en:Mol Biol Cell
Main Authors: Perera, David, Perez-Hidalgo, Livia, Moens, Peter B., Reini, Kaarina, Lakin, Nicholas, Syväoja, Juhani E., San-Segundo, Pedro A., Freire, Raimundo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Cell Biology 2004
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Articles
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC379256/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14718568/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E03-06-0444
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