TopBP1 and ATR Colocalization at Meiotic Chromosomes: Role of TopBP1/Cut5 in the Meiotic Recombination Checkpoint

Mammalian TopBP1 is a BRCT domain–containing protein whose function in mitotic cells is linked to replication and DNA damage checkpoint. Here, we study its possible role during meiosis in mice. TopBP1 foci are abundant during early prophase I and localize mainly to histone γ-H2AX–positive domains, w...

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Publié dans:	Mol Biol Cell
Auteurs principaux:	Perera, David, Perez-Hidalgo, Livia, Moens, Peter B., Reini, Kaarina, Lakin, Nicholas, Syväoja, Juhani E., San-Segundo, Pedro A., Freire, Raimundo
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Cell Biology 2004
Sujets:	Articles
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC379256/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14718568/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E03-06-0444
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