Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt

Cdk2-dependent TopBP1-treslin interaction is critical for DNA replication initiation. However, it remains unclear how this association is terminated after replication initiation is finished. Here, we demonstrate that phosphorylation of TopBP1 by Akt coincides with cyclin A activation during S and G(...

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Udgivet i:Mol Cell Biol
Main Authors: Liu, Kang, Graves, Joshua D., Lee, Yu-Ju, Lin, Fang-Tsyr, Lin, Weei-Chin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108819/
https://ncbi.nlm.nih.gov/pubmed/31964753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00599-19
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