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Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt
Cdk2-dependent TopBP1-treslin interaction is critical for DNA replication initiation. However, it remains unclear how this association is terminated after replication initiation is finished. Here, we demonstrate that phosphorylation of TopBP1 by Akt coincides with cyclin A activation during S and G(...
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| Udgivet i: | Mol Cell Biol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7108819/ https://ncbi.nlm.nih.gov/pubmed/31964753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00599-19 |
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