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Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt

Cdk2-dependent TopBP1-treslin interaction is critical for DNA replication initiation. However, it remains unclear how this association is terminated after replication initiation is finished. Here, we demonstrate that phosphorylation of TopBP1 by Akt coincides with cyclin A activation during S and G(...

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Podrobná bibliografie
Vydáno v:Mol Cell Biol
Hlavní autoři: Liu, Kang, Graves, Joshua D., Lee, Yu-Ju, Lin, Fang-Tsyr, Lin, Weei-Chin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108819/
https://ncbi.nlm.nih.gov/pubmed/31964753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00599-19
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