CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation

Ultraviolet (UV)-induced DNA damage causes an efficient block of elongating replication forks. The checkpoint kinase, CHK1 has been shown to stabilize replication forks following hydroxyurea treatment. Therefore, we wanted to test if the increased UV sensitivity caused by the unspecific kinase inhib...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Elvers, Ingegerd, Hagenkort, Anna, Johansson, Fredrik, Djureinovic, Tatjana, Lagerqvist, Anne, Schultz, Niklas, Stoimenov, Ivaylo, Erixon, Klaus, Helleday, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458576/
https://ncbi.nlm.nih.gov/pubmed/22753029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks646
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky