CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation

Ultraviolet (UV)-induced DNA damage causes an efficient block of elongating replication forks. The checkpoint kinase, CHK1 has been shown to stabilize replication forks following hydroxyurea treatment. Therefore, we wanted to test if the increased UV sensitivity caused by the unspecific kinase inhib...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Elvers, Ingegerd, Hagenkort, Anna, Johansson, Fredrik, Djureinovic, Tatjana, Lagerqvist, Anne, Schultz, Niklas, Stoimenov, Ivaylo, Erixon, Klaus, Helleday, Thomas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2012
Gaiak:
Genome Integrity, Repair and Replication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458576/
https://ncbi.nlm.nih.gov/pubmed/22753029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks646
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