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CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation
Ultraviolet (UV)-induced DNA damage causes an efficient block of elongating replication forks. The checkpoint kinase, CHK1 has been shown to stabilize replication forks following hydroxyurea treatment. Therefore, we wanted to test if the increased UV sensitivity caused by the unspecific kinase inhib...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3458576/ https://ncbi.nlm.nih.gov/pubmed/22753029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks646 |
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