CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation

Ultraviolet (UV)-induced DNA damage causes an efficient block of elongating replication forks. The checkpoint kinase, CHK1 has been shown to stabilize replication forks following hydroxyurea treatment. Therefore, we wanted to test if the increased UV sensitivity caused by the unspecific kinase inhib...

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Detalhes bibliográficos
Main Authors: Elvers, Ingegerd, Hagenkort, Anna, Johansson, Fredrik, Djureinovic, Tatjana, Lagerqvist, Anne, Schultz, Niklas, Stoimenov, Ivaylo, Erixon, Klaus, Helleday, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458576/
https://ncbi.nlm.nih.gov/pubmed/22753029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks646
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