Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression

The ATR-Chk1 and ATM-Chk2 pathways are central in DNA damage repair (DDR) and their over-activation may confer aggressive molecular features, being an adaptive response to endogenous DNA damage and oncogene-induced replication stress. Herein we investigated the ATR-Chk1 and ATM-Chk2 signalings in ma...

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Publicado no:Sci Rep
Main Authors: Di Benedetto, Anna, Ercolani, Cristiana, Mottolese, Marcella, Sperati, Francesca, Pizzuti, Laura, Vici, Patrizia, Terrenato, Irene, Shaaban, Abeer M., Humphries, Matthew P., Di Lauro, Luigi, Barba, Maddalena, Vitale, Ilio, Ciliberto, Gennaro, Speirs, Valerie, De Maria, Ruggero, Maugeri-Saccà, Marcello
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556084/
https://ncbi.nlm.nih.gov/pubmed/28808232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07366-7
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