Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is increased after CHK1 inhibition, we hypothesized that this may indicate an increased reliance on ATR for survival. Indeed, we observe that r...

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Udgivet i:Cell Rep
Main Authors: Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Charlton, Peter A., Pollard, John R., Berglund, Ulrika Warpman, Altun, Mikael, Helleday, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713868/
https://ncbi.nlm.nih.gov/pubmed/26748709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.032
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