PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

If replication forks are perturbed, a multifaceted response including several DNA repair and cell cycle checkpoint pathways is activated to ensure faithful DNA replication. Here, we show that poly(ADP-ribose) polymerase 1 (PARP1) binds to and is activated by stalled replication forks that contain sm...

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Detalhes bibliográficos
Main Authors: Bryant, Helen E, Petermann, Eva, Schultz, Niklas, Jemth, Ann-Sofie, Loseva, Olga, Issaeva, Natalia, Johansson, Fredrik, Fernandez, Serena, McGlynn, Peter, Helleday, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738702/
https://ncbi.nlm.nih.gov/pubmed/19629035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.206
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