PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

If replication forks are perturbed, a multifaceted response including several DNA repair and cell cycle checkpoint pathways is activated to ensure faithful DNA replication. Here, we show that poly(ADP-ribose) polymerase 1 (PARP1) binds to and is activated by stalled replication forks that contain sm...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Bryant, Helen E, Petermann, Eva, Schultz, Niklas, Jemth, Ann-Sofie, Loseva, Olga, Issaeva, Natalia, Johansson, Fredrik, Fernandez, Serena, McGlynn, Peter, Helleday, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738702/
https://ncbi.nlm.nih.gov/pubmed/19629035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.206
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars