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NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine
Thiopurines are a standard treatment for childhood leukemia, but like all chemotherapeutics their use is limited by inherent or acquired resistance in patients. Recently, the nucleoside diphosphate hydrolase NUDT15 has received attention based on its ability to hydrolyze the thiopurine effector meta...
Kaydedildi:
| Yayımlandı: | Cancer Res |
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| Asıl Yazarlar: | , , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6847052/ https://ncbi.nlm.nih.gov/pubmed/27530327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0584 |
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