NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine

Thiopurines are a standard treatment for childhood leukemia, but like all chemotherapeutics their use is limited by inherent or acquired resistance in patients. Recently, the nucleoside diphosphate hydrolase NUDT15 has received attention based on its ability to hydrolyze the thiopurine effector meta...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Valerie, Nicholas C.K., Hagenkort, Anna, Page, Brent D.G., Masuyer, Geoffrey, Rehling, Daniel, Carter, Megan, Bevc, Luka, Herr, Patrick, Homan, Evert, Sheppard, Nina G., Stenmark, Pål, Jemth, Ann-Sofie, Helleday, Thomas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847052/
https://ncbi.nlm.nih.gov/pubmed/27530327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0584
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