Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B

Por Schoenfeld, Ryan C., Bourdet, David L., Brameld, Ken A., Chin, Elbert, de Vicente, Javier, Fung, Amy, Harris, Seth F., Lee, Eun K., Pogam, Sophie Le, Leveque, Vincent, Li, Jim, Lui, Alfred S-T., Najera, Isabel, Rajyaguru, Sonal, Sangi, Michael, Steiner, Sandra, Talamas, Francisco X., Taygerly, Joshua P., Zhao, Junping
Publicado em 2013

Redox-based probes as tools to monitor oxidized protein tyrosine phosphatases in living cells

Por Garcia, Francisco J., Carroll, Kate S.
Publicado no Eur J Med Chem (2014)

6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site

Por Ghizzoni, Massimo, Wu, Jiang, Gao, Tielong, Haisma, Hidde J., Dekker, Frank J., Zheng, Y. George
Publicado em 2011

A Molecular Model for Cocaine Binding by the Immunotherapeutic Human/Mouse Chimeric Monoclonal Antibody 2E2

Por Lape, Michael, Paula, Stefan, Ball, William J.
Publicado em 2010

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

Por Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Publicado no Eur J Med Chem (2016)

Design of a novel Thiophene Inhibitor of 15-Lipoxygenase-1 with both Anti-inflammatory and Neuroprotective Properties

Por Eleftheriadis, Nikolaos, Poelman, Hessel, Leus, Niek G. J., Honrath, Birgit, Neochoritis, Constantinos G., Dolga, Amalia, Dömling, Alexander, Dekker, Frank J.
Publicado no Eur J Med Chem (2016)

Modeling, Synthesis and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Novel Analogs of 4-[1-(3,5,5,8,8- Pentamethyl-5,6,7,8-tetrahydro-2- naphthy...

Por Wagner, Carl E., Jurutka, Peter W., Marshall, Pamela A., Groy, Thomas L., van der Vaart, Arjan, Ziller, Joseph W., Furmick, Julie K., Graeber, Mark E., Matro, Erik, Miguel, Belinda V., Tran, Ivy T., Kwon, Jeng Eun S., Tedeschi, Jamie N., Moosavi, Shahram, Danishyar, Amina, Philp, Joshua S., Khamees, Reina O., Jackson, Jevon N., Grupe, Darci K., Badshah, Syed L., Hart, Justin W.
Publicado em 2009

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

Por Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael, Avery, Vicky M., Suckling, Colin J.
Publicado no Eur J Med Chem (2016)

Structure-Guided Design of Novel Trypanosoma brucei Methionyl-tRNA Synthetase Inhibitors

Por Huang, Wenlin, Zhang, Zhongsheng, Barros-Álvarez, Ximena, Koh, Cho Yeow, Ranade, Ranae M., Gillespie, J. Robert, Creason, Sharon A., Shibata, Sayaka, Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., Fan, Erkang
Publicado no Eur J Med Chem (2016)

Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver

Por Hoeger, Birgit, Diether, Maren, Ballester, Pedro J., Köhn, Maja
Publicado no Eur J Med Chem (2014)

Synthesis and pharmacological evaluation of indole-based sigma receptor ligands

Por Mésangeau, Christophe, Amata, Emanuele, Alsharif, Walid, Seminerio, Michael J., Robson, Matthew J., Matsumoto, Rae R., Poupaert, Jacques H., McCurdy, Christopher R.
Publicado em 2011

The relevance of K(i) calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor

Por Wapenaar, Hannah, van den Bosch, Thea, Leus, Niek G. J., van der Wouden, Petra E., Eleftheriadis, Nikolaos, Hermans, Jos, Hailu, Gebremedhin Solomon, Rotili, Dante, Mai, Antonello, Dömling, Alexander, Bischoff, Rainer, Haisma, Hidde J., Dekker, Frank J.
Publicado no Eur J Med Chem (2017)

2-(3-Fluoro-4-methylsulfonylaminophenyl) Propanamides as Potent Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists: Structure Activity Relationships of 2-Amino Derivative...

Por Kim, Myeong Seop, Ryu, HyungChul, Kang, Dong Wook, Cho, Seong-Hee, Seo, Sejin, Park, Young Soo, Kim, Mi-Yeon, Kwak, Eun Joo, Kim, Yong Soo, Bhondwe, Rahul S., Kim, Ho Shin, Park, Seul-gi, Son, Karam, Choi, Sun, DeAndrea-Lazarus, Ian, Pearce, Larry V., Blumberg, Peter M., Frank, Robert, Bahrenberg, Gregor, Stockhausen, Hannelore, Kögel, Babette Y., Schiene, Klaus, Christoph, Thomas, Lee, Jeewoo
Publicado em 2012

Synthesis and Biological Evaluation of Novel Hybrids of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists

Por Zhang, Han-Kun, Eaton, J. Brek, Fedolak, Allison, Gunosewoyo, Hendra, Onajole, Oluseye K., Brunner, Dani, Lukas, Ronald J., Yu, Li-Fang, Kozikowski, Alan P.
Publicado no Eur J Med Chem (2016)

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

Por Baud, Matthias G.J., Bauer, Matthias R., Verduci, Lorena, Dingler, Felix A., Patel, Ketan J., Horil Roy, Deeptee, Joerger, Andreas C., Fersht, Alan R.
Publicado no Eur J Med Chem (2018)

Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors

Por Binder, Randall J., Hatfield, M. Jason, Chi, Liying, Potter, Philip M.
Publicado no Eur J Med Chem (2018)

Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor

Por Grieco, Paolo, Brancaccio, Diego, Novellino, Ettore, Hruby, Victor J., Carotenuto, Alfonso
Publicado no Eur J Med Chem (2011)

Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents

Por Luo, Zonghua, Rosenberg, Adam J., Liu, Hui, Han, Junbin, Tu, Zhude
Publicado no Eur J Med Chem (2018)

Synthesis and Biological Evaluation of Isomeric Methoxy Substitutions on Anti-Cancer Indolyl-Pyridinyl-Propenones: Effects on Potency and Mode of Activity

Por Trabbic, Christopher J., George, Sage M., Alexander, Evan M., Du, Shengnan, Offenbacher, Jennifer M., Crissman, Emily J., Overmeyer, Jean H., Maltese, William A., Erhardt, Paul W.
Publicado no Eur J Med Chem (2016)

Structure-Activity Relationships of Potentiators of the Antibiotic Activity of Clarithromycin against Escherichia coli

Por Blankson, Gifty, Parhi, Ajit K., Kaul, Malvika, Pilch, Daniel S., LaVoie, Edmond J.
Publicado no Eur J Med Chem (2019)