Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked

Por Wisastra, Rosalina, Dekker, Frank J.
Publicado em 2014

Histone acetyltransferases: challenges in targeting bi-substrate enzymes

Por Wapenaar, Hannah, Dekker, Frank J.
Publicado no Clin Epigenetics (2016)

Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases

Por Dekker, Frank J., van den Bosch, Thea, Martin, Nathaniel I.
Publicado no Drug Discov Today (2011)

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

Por Leus, Niek G.J., Zwinderman, Martijn R.H., Dekker, Frank J.
Publicado no Curr Opin Chem Biol (2016)

Metabolic alkene labeling and in vitro detection of histone acylation via the aqueous oxidative Heck reaction

Por Ourailidou, Maria E., Dockerty, Paul, Witte, Martin, Poelarends, Gerrit J., Dekker, Frank J.
Publicado no Org Biomol Chem (2015)

Light-controlled HDAC inhibitors: towards photopharmacological chemotherapy

Por Szymanski, Wiktor, Ourailidou, Maria E., Velema, Willem A., Dekker, Frank J., Feringa, Ben L.
Publicado no Chemistry (2015)

Towards the development of activity-based probes for detection of Lysine-Specific Demethylase-1 activity

Por Ourailidou, Maria E., Lenoci, Alessia, Zwergel, Clemens, Rotili, Dante, Mai, Antonello, Dekker, Frank J.
Publicado no Bioorg Med Chem (2016)

6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site

Por Ghizzoni, Massimo, Wu, Jiang, Gao, Tielong, Haisma, Hidde J., Dekker, Frank J., Zheng, Y. George
Publicado em 2011

Activity-Based Probes for 15-lipoxygenase-1

Por Eleftheriadis, Nikolaos, Thee, Stephanie A., Zwinderman, Martijn R. H., Leus, Niek G. J., Dekker, Frank J.
Publicado no Angew Chem Int Ed Engl (2016)

Enzyme kinetics and inhibition of histone acetyltransferase KAT8

Por Wapenaar, Hannah, van der Wouden, Petra E., Groves, Matthew R., Rotili, Dante, Mai, Antonello, Dekker, Frank J.
Publicado no Eur J Med Chem (2015)

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

Por Xu, Jin, Hedberg, Christian, Dekker, Frank J., Li, Qing, Haigis, Kevin M., Hwang, Eugene, Waldmann, Herbert, Shannon, Kevin
Publicado em 2012

Rational development of a potent 15-lipoxygenase-1 inhibitor with in vitro and ex vivo anti-inflammatory properties

Por Eleftheriadis, Nikolaos, Neochoritis, Constantinos G., Leus, Niek G.J., van der Wouden, Petra E., Dömling, Alexander, Dekker, Frank J.
Publicado no J Med Chem (2015)

Raft Protein Clustering Alters N-Ras Membrane Interactions and Activation Pattern

Por Eisenberg, Sharon, Beckett, Alison J., Prior, Ian A., Dekker, Frank J., Hedberg, Christian, Waldmann, Herbert, Ehrlich, Marcelo, Henis, Yoav I.
Publicado em 2011

Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection

Por Wisastra, Rosalina, Kok, Petra A.M, Eleftheriadis, Nikolaos, Baumgartner, Matthew P., Camacho, Carlos J., Haisma, Hidde J., Dekker, Frank J.
Publicado em 2013

Design of a novel Thiophene Inhibitor of 15-Lipoxygenase-1 with both Anti-inflammatory and Neuroprotective Properties

Por Eleftheriadis, Nikolaos, Poelman, Hessel, Leus, Niek G. J., Honrath, Birgit, Neochoritis, Constantinos G., Dolga, Amalia, Dömling, Alexander, Dekker, Frank J.
Publicado no Eur J Med Chem (2016)

Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans

Por Raj, Hans, Puthan Veetil, Vinod, Szymanski, Wiktor, Dekker, Frank J., Quax, Wim J., Feringa, Ben L., Janssen, Dick B., Poelarends, Gerrit J.
Publicado em 2011

Aqueous Oxidative Heck Reaction as a Protein-Labeling Strategy

Por Ourailidou, Maria Eleni, van der Meer, Jan-Ytzen, Baas, Bert-Jan, Jeronimus-Stratingh, Margot, Gottumukkala, Aditya L, Poelarends, Gerrit J, Minnaard, Adriaan J, Dekker, Frank J
Publicado em 2014

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases

Por van den Bosch, Thea, Boichenko, Alexander, Leus, Niek G. J., Eleni Ourailidou, Maria, Wapenaar, Hannah, Rotili, Dante, Mai, Antonello, Imhof, Axel, Bischoff, Rainer, Haisma, Hidde J., Dekker, Frank J.
Publicado no Biochem Pharmacol (2015)

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional a...

Por Leus, Niek G.J., van der Wouden, Petra E., van den Bosch, Thea, Hooghiemstra, Wouter T.R., Ourailidou, Maria E., Kistemaker, Loes E.M., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.
Publicado no Biochem Pharmacol (2016)

HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

Por Leus, Niek G. J., van den Bosch, Thea, van der Wouden, Petra E., Krist, Kim, Ourailidou, Maria E., Eleftheriadis, Nikolaos, Kistemaker, Loes E. M., Bos, Sophie, Gjaltema, Rutger A. F., Mekonnen, Solomon A., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.
Publicado no Sci Rep (2017)